pdms

A POLYMER-BASED MICROFLUIDIC RESISTIVE SENSOR FOR DETECTING DISTRIBUTED LOADS

This poster presents a polymer-based microfluidic resistive sensor for detecting distributed loads. The sensor is comprised of a polymer rectangular microstructure with an embedded electrolyte-filled microchannel and an array of electrodes aligned along the microchannel length. Electrolyte solution in the microchannel serves as impedance transduction. Distributed loads acting on the polymer microstructure give rise to different deflection along the microstructure length, which is recorded as the resistance change in electrolyte solution. This sensor can detect distributed loads by monitoring the resistance change at each pair of electrodes. Owing to great simplicity of the device configuration, a standard polymer-based fabrication process is employed to fabricate this device. With custom-built electronic circuits and custom LabVIEW programs, fabricated devices filled with two different electrolytes, 0.1M NaCl electrolyte and 1-Ethyl-3-methylimidazolium dicyanamide electrolyte, are characterized, demonstrating the capability of detecting distributed static and dynamic loads with a single device.
Listed In: Biomechanical Engineering


Developing a Microloading Platform for Applications in Mechanotransduction Research

Bone cell mechanotransduction involves the process by which bone cells sense and coordinate their activity in response to mechanical loading. Classic mechanotransduction models include the parallel plate flow and cone viscometer systems. These systems apply fluid flow to bone cells to study the effects of fluid shear on cellular activity. In this study a microactuated loading device to subject bone cells to a complex state of deformation utilizing a deformable membrane was developed. To model the loading profile, finite element analysis was utilized with material properties of polydimethylsiloxane (PDMS) determined from mechanical testing to model a cell substrate and loading platen to apply accurate, reproducible and physiologically appropriate loading.
Listed In: Biomechanical Engineering