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Metrics of multi-muscle synergies in Parkinson’s disease: Analysis of variance and motor equivalence

Conference: Progress in Motor Control XI
Abstract: Over the past years, we have developed a test for postural stability based on the theory of synergies stabilizing salient performance variables. In this study, effects of Parkinson's disease (PD) and dopamine-replacement therapy on multi-muscle synergies stabilizing the center of pressure (COP) coordinate were explored between: (1) a cohort of 11 patients without clinically identifiable postural problems (Hoehn-Yahr stage II) and 11 age-matched controls, and (2) a cohort of 10 patients tested off- and on-medication, with and without postural problems (stage II and III, n = 5 per stage). Participants stood on a force platform and performed cyclical body sway at 0.5 Hz along the anterior-posterior direction. Electromyographic signals from 13 leg and trunk muscles were used to compute: (1) the amount of inter-cycle variance that did not affect (VUCM) and affected (VORT) COP coordinate, and (2) the magnitude of the cycle-to-cycle motion that did not change (motor equivalent: ME) and changed (non-motor equivalent: nME) the COP coordinate. We hypothesized that both methods would produce indices sensitive to PD and dopaminergic medications. Compared to controls, patients showed significantly smaller inter-cycle VUCM and ME components suggesting a less flexible, and hence less stable, behavior. Moreover, inter-cycle variance within/orthogonal to the UCM correlated with ME/nME displacements. Results suggest clinical utility of variance and motor equivalence analyses of postural instability in early stages of PD and quantifying the effects of dopamine-replacement drugs. The analysis of motor equivalence is particularly attractive because it requires only a handful of trials (observations).
Listed In: Neuroscience,
Tagged In: Human motor control, Motor equivalence, Parkinson's Disease, Posture, stability, synergy

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